Carbonic Anhydrase Inhibitors

Carbonic Anhydrase Inhibitors

Mechanism of action:
They affect the carbonic Anhydrase formation, an enzyme that affects acid-base balance by ability to form carbonic acid from water and carbon dioxide.

  • Acetazolamide
  • Methazolamide
  • Brinzolamide
  • Dorzolamide

Their clinical use has been established as

  • antiglaucoma agents
  • diuretics (rarely used)
  • antiepileptic
  • In the management of mountain sickness, gastric and duodenal ulcers,
  • Neurological disorders
  • Osteoporosis

Side effects:
Side effects of carbonic Anhydrase inhibitors that are taken by mouth or given through a vein include:

  • Bitter taste in the mouth
  • Sluggishness
  • Tingling in the hands and feet (Many people who take the oral form of these medicines develop this side effect.)
  • Decreased appetite and weight loss
  • Kidney stones
  • Low potassium levels in the body.
  • Skin reaction
  • Depression and decreased sex drive (less common).
  • Anemia (very rare)