Carbonic Anhydrase Inhibitors
Mechanism of action:
They affect the carbonic Anhydrase formation, an enzyme that affects acid-base balance by ability to form carbonic acid from water and carbon dioxide.
Their clinical use has been established as
- antiglaucoma agents
- diuretics (rarely used)
- In the management of mountain sickness, gastric and duodenal ulcers,
- Neurological disorders
Side effects of carbonic Anhydrase inhibitors that are taken by mouth or given through a vein include:
- Bitter taste in the mouth
- Tingling in the hands and feet (Many people who take the oral form of these medicines develop this side effect.)
- Decreased appetite and weight loss
- Kidney stones
- Low potassium levels in the body.
- Skin reaction
- Depression and decreased sex drive (less common).
- Anemia (very rare)