Insulin for Type I Diabetes

Types of Insulin

Action Drug Onset Peak Duration Timing Remarks
Rapid Acting insulin aspart (Novolog) 10-20 min 1-3 hrs 3-5 hrs Before meals
ac
Clear
Can mix with NPH.
insulin lispro (Humalog) 5-15 min 1-1.5 hrs 3-4 hrs
Insulin glulisine (Apidra) 15-30 min 1 hr 3-4 hrs
Short
Acting
insulin regular
(Humulin R, Novolin R)
30-60 min 1-5 hrs 6-10 hrs ac Clear
Can give SQ or IV
Can mix with NPH, sterile water or NS.
Intermediate
Acting
isophane suspension
(NPH, Humulin N)
1-2 hrs 6-14 hrs 16-24 hrs Cloudy
Long
Acting
insulin detemir
(Levemir)
Gradual 6-8 hrs Up to 24 hrs 1-2 times per day Clear
Do not mix with other insulins.
insulin glargine (Lantus) 1.1 hrs No peak 1 time per day Clear
May seen given at hs
Do not mix with other insulins.


Source: Adams, M.P., & Holland, L.N. (2011). Pharmacology for nurses: A pathophysiologic approach. Pearson; Boston, Mass.